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Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

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Kim S, et al

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This maintains the natural pulsatile pattern that the hypothalamic-pituitary axis expects, reducing the risk of desensitization